I Prescribe : Urolithin A

Urolithin A is a compound produced in the human gut, when certain types of polyphenols, primarily from foods like pomegranates and berries, are metabolised by intestinal bacteria. 

Neurolithin, commonly referred to as Urolithin A, is a compound formed in the gut when ellagitannins from foods like pomegranates, berries (raspberries, blackberries, strawberries), and nuts (especially walnuts and pecans) are metabolised by specific gut bacteria. This conversion varies by individual, as not everyone has the required microbiome composition to efficiently produce Urolithin A from these foods.

In terms of supplementation, Urolithin A is available in pharmaceutical-grade forms, with Mitopure by Amazentis being the only brand clinically validated for efficacy. Research has shown that 500 mg of Mitopure daily can support mitochondrial function, increase muscle strength, and enhance cellular health in older adults, promoting longevity and aiding in conditions associated with mitochondrial dysfunction such as osteoarthritis and certain neurodegenerative diseases. 

Additionally, it may benefit immune function and even support reproductive longevity and brain health by inducing processes like mitophagy and autophagy, which are crucial for cellular renewal and function.

Safety studies have indicated that urolithin A is generally well-tolerated, with the FDA approving it as safe for food products at doses between 250 mg to 1 gram per serving. However, individuals interested in supplementing with it should consult with healthcare providers, especially those with pre-existing conditions or who take medication, to ensure compatibility and optimal dosage.

3. Muscle Endurance: Preliminary research indicates that as a supplementation it might improve muscle endurance and strength, particularly in older adults.